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One of major drawbacks of orthogonal frequency division multiplexing (OFDM) systems is the high peak-to-average power ratio (PAPR). A signal with high PAPR leads to nonlinear distortion caused mainly by power amplifiers in wireless transmitters. Partial transmit sequence (PTS) is one of the most attractive methods to reduce the PAPR in OFDM systems. It achieves considerable PAPR reduction without distortion, but it requires an exhaustive search over all the combinations of the given phase factors, which results in a computational complexity that increases exponentially with the number of partitions. For this optimization problem, we propose in this paper a suboptimal PTS method based on the self-adaptive multipopulation differential evolution algorithm (SAMDE). The self adaptation of control parameters and structured population, is able to obtain high quality solutions with low computational cost by evolving each sub-population of individuals over successive generations.