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Identification of informative genes is essential for the disease and cancer studies. Metaheuristic algorithms have been widely used for this purpose. However, their performance on various high-dimensional datasets of genomic studies has not been fully addressed. This work was intended to perform a comprehensive comparative analysis on three well-known nature-inspired metaheuristic algorithms, namely binary particle swarm optimization (BPSO), genetic algorithm (GA) and cuckoo search algorithm (CS) when they are used in gene selection and classification in twelve high-dimensional cancer datasets. The methodology was carried out through the utilization of a three-phase hybrid approach, considering a pre-processing filtration using Pearson product-moment correlation coefficient (PPMCC) followed by the metaheuristic and classification algorithms. Comparably, five different classification …