作者
Paolo Manzoni, Michael Meyer, Ilaria Stolfi, Matteo Rinaldi, Silvia Cattani, Lorenza Pugni, Mario Giovanni Romeo, Hubert Messner, Lidia Decembrino, Nicola Laforgia, Federica Vagnarelli, Luigi Memo, Linda Bordignon, Milena Maule, Elena Gallo, Michael Mostert, Michele Quercia, Lina Bollani, Roberto Pedicino, Livia Renzullo, Pasqua Betta, Fabrizio Ferrari, Tanith Alexander, Rosario Magaldi, Daniele Farina, Fabio Mosca, Mauro Stronati
发表日期
2014/3/1
期刊
Early human development
卷号
90
页码范围
S60-S65
出版商
Elsevier
简介
Importance
NEC is a common and severe complication in premature neonates, particularly those with very-low-birth-weight (VLBW, <1500 g at birth). Probiotics including lactobacillus rhamnosus GG (LGG) proved effective in preventing NEC in preterm infants in several RCTs.
Objective
Lactoferrin, a mammalian milk glycoprotein involved in innate immune host defences, can reduce the incidence of NEC in animal models, and its action is enhanced by LGG. We tried to assess whether bovine lactoferrin (BLF), alone or with the probiotic LGG, has a similar effect in human infants, something that has not yet been studied.
Design
An international, multicenter, randomized, double-blind, placebo-controlled trial conducted from October 1st, 2007 through July 31st, 2010.
Setting
Thirteen Italian and New Zealand tertiary neonatal intensive care units.
Participants
743 VLBW neonates were assessed until discharge for …
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P Manzoni, M Meyer, I Stolfi, M Rinaldi, S Cattani… - Early human development, 2014