作者
Paolo Manzoni, Matteo Rinaldi, Silvia Cattani, Lorenza Pugni, Mario Giovanni Romeo, Hubert Messner, Ilaria Stolfi, Lidia Decembrino, Nicola Laforgia, Federica Vagnarelli, Luigi Memo, Linda Bordignon, Onofrio Sergio Saia, Milena Maule, Elena Gallo, Michael Mostert, Cristiana Magnani, Michele Quercia, Lina Bollani, Roberto Pedicino, Livia Renzullo, Pasqua Betta, Fabio Mosca, Fabrizio Ferrari, Rosario Magaldi, Mauro Stronati, Daniele Farina
发表日期
2009/10/7
期刊
Jama
卷号
302
期号
13
页码范围
1421-1428
出版商
American Medical Association
简介
Context
Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) (<1500 g). Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is unknown. In animal models, the probiotic Lactobacillus rhamnosus GG (LGG) enhances the activity of lactoferrin but has not been studied in human infants.
Objective
To establish whether bovine lactoferrin (BLF), alone or in combination with LGG, reduces the incidence of late-onset sepsis in VLBW neonates.
Design, Setting, and Patients
Prospective, multicenter, double-blind, placebo-controlled, randomized trial conducted in 11 Italian tertiary neonatal intensive care units. Patients were 472 VLBW infants enrolled from October 1, 2007, through July 31, 2008, and assessed until discharge for development of sepsis.
Intervention
Infants were randomly …
引用总数
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P Manzoni, M Rinaldi, S Cattani, L Pugni, MG Romeo… - Jama, 2009