作者
Mohammad R Alipour, Nasibeh Yousefzade, Fariba Mirzaei Bavil, Roya Naderi, Rafighe Ghiasi
发表日期
2020/11/1
期刊
Current Diabetes Reviews
卷号
16
期号
8
页码范围
889-894
出版商
Bentham Science Publishers
简介
Background
Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and type-2 diabetes.
Objective
This study aimed to evaluate the effect of swimming exercise on pancreatic expression levels of inflammatory cytokines, miR-146a and NF-ΚB in type-2 diabetic male rats.
Methods
Twenty- eight male Wistar rats were divided into four groups: control (Con), exercise, diabetes and diabetic exercise (n = 7). Diabetes induction performed by the combination of high-fat diet (HFD, 4 weeks) and streptozotocin (35 mg/kg. ip). After induction of diabetes, the rats swam in the exercise groups for 12 weeks. Then, blood and tissue samples were collected.
Results
Our results indicated a significant increase in expression levels of miR-146, NF-ΚB and inflammatory cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression levels of TRAF6 and IRAK1 in …
引用总数
2020202120222023202442134