作者
Nasibeh Yousefzadeh, Sajad Jeddi, Hamideh Afzali, Khosrow Kashfi, Asghar Ghasemi
发表日期
2022/10
期刊
Cell Biochemistry and Function
卷号
40
期号
7
页码范围
750-759
简介
Nitrate, a nitric oxide (NO) donor, has antiobesity effect in female rats. This study hypothesized that the antiobesity effect of nitrate in female rats is due to the browning of white adipose tissue (WAT). Female Wistar rats (aged 8 months) were divided into two groups (n = 10/group): the control group received tap water and the nitrate group received water containing 100 mg/L of sodium nitrate for 9 months. At months 0, 3, 6, and 9, obesity indices were measured. At month 9, gonadal adipose tissue was used to measure messenger RNA (mRNA) and protein levels of peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), PPAR‐γ coactivator 1‐α (PGC1‐α), uncoupling protein 1 (UCP1), and adipocyte density and area. After the 9‐month intervention, nitrate‐treated rats had lower body weight, body mass index, thoracic circumference, and abdominal circumference by 6.4% (p = .012), 9.1% (p = .029), 6.0% (p …
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