作者
Nasibeh Yousefzadeh, Sajad Jeddi, Maryam Zarkesh, Reza Norouzirad, Khosrow Kashfi, Asghar Ghasemi
发表日期
2023/8
期刊
Pharmacological Reports
卷号
75
期号
4
页码范围
979-994
出版商
Springer International Publishing
简介
Background
Menopause is associated with higher risks of chronic kidney disease. We determined the effect of nitrate on ovariectomy-induced kidney dysfunction
Methods
Control, ovariectomized (OVX), control + nitrate, and OVX + nitrate female Wistar rats (n = 10/group); sodium nitrate (100 mg/L) administered in drinking water for 9 months. Glomerular filtration rate (GFR) and albumin excretion rate (AER) were calculated from serum and urine parameters. At month 9, serum and kidney levels of nitric oxide (NO) metabolites (NOx), oxidative stress indices, and mRNA expression of endothelial NO synthase (eNOS) were measured; with histological analyses of the kidney.
Results
Compared to controls, OVX rats had lower GFR (31%, p = 0.0079), higher glomerular tuft volume (30%, p = 0.0402), and Bowman’s capsule space (39%, p = 0.0224). OVX rats had lower serum NOx (33%, p = 0.0061) and kidney …
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N Yousefzadeh, S Jeddi, M Zarkesh, R Norouzirad… - Pharmacological Reports, 2023