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Purpose: In this research, synthesis, characterization and evaluation of in vitro biocompatibility of a nanocomposite as an artificial cornea have been carried out.

Methods: A scaffold with transparent center from poly vinyl alcohol (PVA) hydrogel, which is surrounded by modified bacterial cellulose (BC)-porous poly vinyl alcohol-nano hydroxy apatite (nHA) composite, was designed. In situ synthesis of nHA in PVA matrix was carried out via biomimetic method. The whole scaffold was made by casting, freezing and thawing cycles. Composite was characterized by FT-IR, XRD and SEM. Biocompatibility of composite was studied by cultivating retinal pigment epithelial (RPE) cells on the composite. Water content of hydrogels was also tested.

Results: Results from FT-IR and XRD showed the formation of nHA in PVA matrix due to presence of active sites on polymers for Ca 2+ coordination followed by phosphate bonding …