作者
Conor N Gruber, Roosheel S Patel, Rebecca Trachtman, Lauren Lepow, Fatima Amanat, Florian Krammer, Karen M Wilson, Kenan Onel, Daniel Geanon, Kevin Tuballes, Manishkumar Patel, Konstantinos Mouskas, Timothy O’Donnell, Elliot Merritt, Nicole W Simons, Vanessa Barcessat, Diane M Del Valle, Samantha Udondem, Gurpawan Kang, Charuta Agashe, Neha Karekar, Joanna Grabowska, Kai Nie, Jessica Le Berichel, Hui Xie, Noam Beckmann, Sandeep Gangadharan, George Ofori-Amanfo, Uri Laserson, Adeeb Rahman, Seunghee Kim-Schulze, Alexander W Charney, Sacha Gnjatic, Bruce D Gelb, Miriam Merad, Dusan Bogunovic
发表日期
2020/11/12
期刊
Cell
卷号
183
期号
4
页码范围
982-995. e14
出版商
Elsevier
简介
Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both …
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CN Gruber, RS Patel, R Trachtman, L Lepow, F Amanat… - Cell, 2020