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The aim of this study was to experimentally test the effects of different electromyographic-based prosthetic control modes on user task performance, cognitive workload, and perceived usability to inform further human-centered design and application of these prosthetic control interfaces. We recruited 30 able-bodied participants for a between-subjects comparison of three control modes: direct control (DC), pattern recognition (PR), and continuous control (CC). Multiple human-centered evaluations were used, including task performance, cognitive workload, and usability assessments. To ensure that the results were not task-dependent, this study used two different test tasks, including the clothespin relocation task and Southampton hand assessment procedure-door handle task. Results revealed performance with each control mode to vary among tasks. When the task had high-angle adjustment accuracy …