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Titanium dioxide (TiO₂) particles in the nanometer (nm) size range are widely used in commercial sunscreens. Single particle inductively coupled plasma–mass spectrometry (SP-ICP–MS) is an emerging methodology for nanoparticle (NP) characterization and quantification. In this study, a rapid SP-ICP–MS method was developed to simultaneously determine the primary particle size, size distribution, particle concentration (particles/mL), and mass content (weight percent) of TiO₂ NPs in commercial sunscreens. Quality control data indicated that the developed method was capable of accurately measuring TiO₂ particle size in sunscreen matrix. Four types of commercial sunscreens containing different amounts of TiO₂ were analyzed, and the primary particle sizes detected varied from 32 nm to 40 nm in the different sunscreens tested. TiO₂ existed as TiO₂ particles in the tested sunscreens. The TiO₂ mass contents …