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Fungal infection in the oral cavity is a completely microbes-oriented disease most probably caused due to biofilm formation on the floor of the mouth and its surrounding. Most of the studies revealed that Candida and Asparigellus spp. are frequently isolated fungus. Smoking, alcohol consumption, high intake of carbohydrate diet, loss of salivary function and immunosuppression are colonizing factors and predisposing factors for fungal infection in the oral cavity and may lead to the chronic stage at its severity. Oral candidiasis is an opportunistic infection of the oral cavity and the incidence depends on the age of the patient and certain predisposing factors. There are three varieties of oral candidiasis such as acute candidiasis, chronic candidiasis and angular cheilitis. CD4 T lymphocyte and CD8 T lymphocyte provides primary as well as secondary immunity towards oral fungal infection. Denture wearers, HIV patients, children and elders are mostly infected by an oral fungal infection. This systematic review tends to focus on etiological factor, salivary action, and immunity behind fungal infection in the oral cavity with management and treatment of oral fungal infection.