作者
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca, Ewoud van der Lelij, Frederik Barkhof, Thomas Benke, Christopher PLH Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G Exalto, Evan F Fletcher, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L Koek, Andrea B Maier, Pauline M Maillard, Cheryl R McCreary, Janne M Papma, Yolande AL Pijnenburg, Reinhold Schmidt, Eric E Smith, Rebecca ME Steketee, Esther van den Berg, Wiesje M van der Flier, Vikram Venkatraghavan, Narayanaswamy Venketasubramanian, Meike W Vernooij, Frank J Wolters, Xin Xu, Andreas Horn, Kaustubh R Patil, Simon B Eickhoff, Götz Thomalla, J Matthijs Biesbroek, Geert Jan Biessels, Bastian Cheng, Alzheimer’s Disease Neuroimaging Initiative
发表日期
2024/4/11
期刊
medRxiv
出版商
Cold Spring Harbor Laboratory Preprints
简介
Conclusion:
Measures of WMH-related brain network connectivity significantly improve the prediction of current cognitive performance in memory clinic patients compared to WMH volume as a traditional imaging marker of cerebrovascular disease. This highlights the crucial role of network effects, particularly in attentionrelated brain regions, improving our understanding of vascular contributions to cognitive impairment. Moving forward, refining WMH information with connectivity data could contribute to patient-tailored therapeutic interventions and facilitate the identification of subgroups at risk of cognitive disorders.
学术搜索中的文章
M Petersen, M Coenen, C DeCarli, A De Luca… - medRxiv, 2024