作者
Marvin Petersen, Céleste Chevalier, Felix L Naegele, Thies Ingwersen, Amir Omidvarnia, Felix Hoffstaedter, Kaustubh Patil, Simon B Eickhoff, Renate B Schnabel, Paulus Kirchhof, Eckhard Schlemm, Bastian Cheng, Götz Thomalla, Märit Jensen
发表日期
2024/6/5
期刊
Alzheimer's & Dementia
简介
INTRODUCTION
Atrial fibrillation (AF) is associated with an elevated risk of cognitive impairment and dementia. Understanding the cognitive sequelae and brain structural changes associated with AF is vital for addressing ensuing health care needs.
METHODS AND RESULTS
We examined 1335 stroke‐free individuals with AF and 2683 matched controls using neuropsychological assessments and multimodal neuroimaging. The analysis revealed that individuals with AF exhibited deficits in executive function, processing speed, and reasoning, accompanied by reduced cortical thickness, elevated extracellular free‐water content, and widespread white matter abnormalities, indicative of small vessel pathology. Notably, brain structural differences statistically mediated the relationship between AF and cognitive performance.
DISCUSSION
Integrating a comprehensive analysis approach with extensive clinical and …
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M Petersen, C Chevalier, FL Naegele, T Ingwersen… - Alzheimer's & Dementia, 2024