作者
Caterina Conte, Elisa Fabbrini, Marleen Kars, Bettina Mittendorfer, Bruce W Patterson, Samuel Klein
发表日期
2012/6/1
期刊
Diabetes care
卷号
35
期号
6
页码范围
1316-1321
出版商
American Diabetes Association
简介
OBJECTIVE
To provide a comprehensive assessment of multiorgan insulin sensitivity in lean and obese subjects with normal glucose tolerance.
RESEARCH DESIGN AND METHODS
The hyperinsulinemic-euglycemic clamp procedure with stable isotopically labeled tracer infusions was performed in 40 obese (BMI 36.2 ± 0.6 kg/m2, mean ± SEM) and 26 lean (22.5 ± 0.3 kg/m2) subjects with normal glucose tolerance. Insulin was infused at different rates to achieve low, medium, and high physiological plasma concentrations.
RESULTS
In obese subjects, palmitate and glucose Ra in plasma decreased with increasing plasma insulin concentrations. The decrease in endogenous glucose Ra was greater during low-, medium-, and high-dose insulin infusions (69 ± 2, 74 ± 2, and 90 ± 2%) than the suppression of palmitate Ra (52 ± 4, 68 ± 1, and 79 ± 1%). Insulin …
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C Conte, E Fabbrini, M Kars, B Mittendorfer… - Diabetes care, 2012