作者
Nicola Napoli, Caterina Conte, Claudio Pedone, Elsa S Strotmeyer, Kamil E Barbour, Dennis M Black, Elizabeth J Samelson, Ann V Schwartz
发表日期
2019/8
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
104
期号
8
页码范围
3303-3310
出版商
Endocrine Society
简介
Context
Adults with type 2 diabetes (T2D) have higher fracture risk compared with nondiabetics, despite having higher bone mineral density (BMD). Insulin resistance (IR) has been associated with increased BMD. It is not known if IR increases fracture risk.
Objective
We investigated the relationship among IR HOMA-IR, BMD, and incident nonspine fractures in nondiabetic individuals.
Design
Participants included 2398 community-dwelling, nondiabetic older adults (age 74 ± 3 years, 53% women, 38% black) in the Health, Aging and Body Composition Prospective Cohort Study [median follow-up: 12 (interquartile range: 6) years].
Results
The cut-off values for the HOMA-IR quartiles were 1.05, 1.54, and 2.33. Total hip BMD was 0.104 g/cm2 higher in the fourth vs the first HOMA-IR quartile (P < 0.001). This difference was attenuated after …
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N Napoli, C Conte, C Pedone, ES Strotmeyer… - The Journal of Clinical Endocrinology & Metabolism, 2019