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An efficient product distribution is critical for proper supply chain operations. Many supply chains handle perishable products that decay over time. Due to mismanagement of supply chain operations, a significant portion of perishable products is wasted, resulting in substantial monetary losses. Cross-docking terminals (CDTs) have been widely used in cold supply chains for the product distribution but have not received adequate attention in the scientific literature. To improve the efficiency of perishable product distribution, this study introduces for the first time a novel mixed-integer mathematical formulation for the truck scheduling optimization at a cold-chain CDT. The model explicitly captures the decay of perishable products throughout the service of arriving trucks and accounts for the presence of temperature-controlled storage areas that are specifically designated for perishable products. The objective minimizes …