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Emergencies, such as pandemics (e.g., COVID-19), warrant urgent production and distribution of goods under disrupted supply chain conditions. An innovative logistics solution to meet the urgent demand during emergencies could be the factory-in-a-box manufacturing concept. The factory-in-a-box manufacturing concept deploys vehicles to transport containers that are used to install production modules (i.e., factories). The vehicles travel to customer locations and perform on-site production. Factory-in-a-box supply chain optimization is associated with a wide array of decisions. This study focuses on selection of vehicles for factory-in-a-box manufacturing and decisions regarding the optimal routes within the supply chain consisting of a depot, suppliers, manufacturers, and customers. Moreover, in order to contrast the options of factory-in-a-box manufacturing with those of conventional manufacturing, the location of …