作者
Claus Klingenberg, Kristina S Sobotka, Tracey Ong, Beth J Allison, Georg M Schmölzer, Timothy JM Moss, Graeme R Polglase, Jennifer A Dawson, Peter G Davis, Stuart B Hooper
发表日期
2013/5/1
期刊
Archives of Disease in Childhood-Fetal and Neonatal Edition
卷号
98
期号
3
页码范围
F222-F227
出版商
BMJ Publishing Group
简介
Objective
The 2010 ILCOR neonatal resuscitation guidelines do not specify appropriate inflation times for the initial lung inflations in apnoeic newborn infants. The authors compared three ventilation strategies immediately after delivery in asphyxiated newborn lambs.
Design
Experimental animal study.
Setting
Facility for animal research.
Subjects
Eighteen near-term lambs (weight 3.5–3.9 kg) delivered by caesarean section.
Interventions
Asphyxia was induced by occluding the umbilical cord and delaying ventilation onset (10–11 min) until mean carotid blood pressure (CBP) was ≤22 mm Hg. Animals were divided into three groups (n=6) and ventilation started with: (1) inflation times of 0.5 s at a ventilation rate 60/min, (2) five 3 s inflations or (3) a single 30 s inflation. Subsequent ventilation used inflations at 0.5 s at 60/min for all groups.
Main outcome measures
Times to reach a heart rate (HR) of 120 bpm and a …
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