作者
Philip A Mudd, Jeremy Chase Crawford, Jackson S Turner, Aisha Souquette, Daniel Reynolds, Diane Bender, James P Bosanquet, Nitin J Anand, David A Striker, R Scott Martin, Adrianus CM Boon, Stacey L House, Kenneth E Remy, Richard S Hotchkiss, Rachel M Presti, Jane A O’Halloran, William G Powderly, Paul G Thomas, Ali H Ellebedy
发表日期
2020/11/13
期刊
Science Advances
页码范围
eabe3024
出版商
American Association for the Advancement of Science
简介
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)–class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional …
学术搜索中的文章
PA Mudd, JC Crawford, JS Turner, A Souquette… - Science advances, 2020