作者
Claudia Fagundes, Marie-Noëlle Pépin, Mónica Guevara, Rogelio Barreto, Gregori Casals, Elsa Solà, Gustavo Pereira, Ezequiel Rodríguez, Elisabet Garcia, Verónica Prado, Esteban Poch, Wladimiro Jiménez, Javier Fernández, Vicente Arroyo, Pere Ginès
发表日期
2012/8/1
期刊
Journal of hepatology
卷号
57
期号
2
页码范围
267-273
出版商
Elsevier
简介
BACKGROUND & AIMS
Impairment of kidney function is common in cirrhosis but differential diagnosis remains a challenge. We aimed at assessing the usefulness of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of tubular damage, in the differential diagnosis of impairment of kidney function in cirrhosis.
METHODS
Two-hundred and forty-one patients with cirrhosis, 72 without ascites, 85 with ascites, and 84 with impaired kidney function, were studied. Urinary levels of NGAL were measured by ELISA.
RESULTS
Patients with impaired kidney function had higher urinary NGAL levels compared to patients with and without ascites. Patients with urinary tract infection (n=25) had higher uNGAL values than non-infected patients. Patients with acute tubular necrosis (ATN) had uNGAL levels markedly higher (417μg/g creatinine (239–2242) median and IQ range) compared to those of patients with pre-renal …
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C Fagundes, MN Pépin, M Guevara, R Barreto… - Journal of hepatology, 2012