作者
Sarah Lensen, Diana Osavlyuk, Sarah Armstrong, Caroline Stadelmann, Aurélie Hennes, Emma Napier, Jack Wilkinson, Lynn Sadler, Devashana Gupta, Annika Strandell, Christina Bergh, Kugajeevan Vigneswaran, Wan T Teh, Haitham Hamoda, Lisa Webber, Sarah A Wakeman, Leigh Searle, Priya Bhide, Simon McDowell, Karen Peeraer, Yacoub Khalaf, Cynthia Farquhar
发表日期
2019/1/24
期刊
New England Journal of Medicine
卷号
380
期号
4
页码范围
325-334
出版商
Massachusetts Medical Society
简介
Background
Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF).
Methods
We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysteroscopy). Participants were randomly assigned in a 1:1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle) or no intervention. The primary outcome was live birth.
Results
A total of 1364 women underwent randomization. The frequency of live birth was 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the …
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S Lensen, D Osavlyuk, S Armstrong, C Stadelmann… - New England Journal of Medicine, 2019