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In this Policy brief, we provide an overview of a recently published report by the European Environment Agency: ‘Sustainability transitions: policy and practice’, which we co-authored. We discuss the report’s context and rationale, namely as part of a knowledge brokering process initiated at the EEA since 2015 and intended to explore the practical implications of transitions research for policy. We outline the report’s 10 key messages, which concern core processes, stages and change mechanisms, key cross-cutting themes, and governance-related challenges for steering transition processes. We also reflect on the report’s findings and the broader knowledge development process, identifying a number of topics the transitions community could further investigate, and highlighting challenges and opportunities for science-policy interactions.