作者
Filippo Castiglione, Benedetto Piccoli
发表日期
2006/2
期刊
Bulletin of Mathematical Biology
卷号
68
页码范围
255-274
出版商
Springer-Verlag
简介
We construct a population dynamics model of the competition among immune system cells and generic tumor cells. Then, we apply the theory of optimal control to find the optimal schedule of injection of autologous dendritic cells used as immunotherapeutic agent.
The optimization method works for a general ODE system and can be applied to find the optimal schedule in a variety of medical treatments that have been described by a mathematical model.
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