作者
Daniele Santoni, Marco Pedicini, Filippo Castiglione
发表日期
2008/6/1
期刊
Bioinformatics
卷号
24
期号
11
页码范围
1374-1380
出版商
Oxford University Press
简介
Motivation: An unbalanced differentiation of T helper cells from precursor type TH0 to the TH1 or TH2 phenotype in immune responses often leads to a pathological condition. In general, immune reactions biased toward TH1 responses may result in auto-immune diseases, while enhanced TH2 responses may cause allergic reactions. The aim of this work is to integrate a gene network of the TH differentiation in an agent-based model of the hyper-sensitivity reaction. The implementation of such a system introduces a second level of description beyond the mesoscopic level of the inter-cellular interaction of the agent-based model. The intra-cellular level consists in the cell internal dynamics of gene activation and transcription. The gene regulatory network includes genes-related molecules that have been found to be involved in the differentiation process in TH cells.
Results: The simulator …
学术搜索中的文章
D Santoni, M Pedicini, F Castiglione - Bioinformatics, 2008