作者
Ranjit K Chaudhary, Chhabindra Nepal, Nabin Khanal, Ranjan Pathak, Smith Giri, Vijaya R Bhatt
发表日期
2015/8/1
来源
Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular & Hematological Agents)
卷号
13
期号
2
页码范围
92-97
出版商
Bentham Science Publishers
简介
Objective
Safety and efficacy of therapeutic agents used for heparin-induced thrombocytopenia are not established in pregnancy.
Methods
MEDLINE database was searched in November 2014 to identify all patients who received therapy for HIT during pregnancy.
Results
A total of 12 patients with the median age of 28 years (range 21-39) were diagnosed with HIT at the median gestational age of 20 weeks (range 5-34). Clinical probability (4T) score for HIT was high (50%) or intermediate (50%) and associated with thrombosis in 50%. Patients were initially managed with lepirudin (33%), argatroban (25%), danaparoid (25%) or fondaparinux (17%) and ultimately bridged to vitamin K antagonist or maintained on lepirudin. All patients had resolution of HIT. Complications included therapeutic abortion prior to valve replacement for valve thrombosis (8%), preterm delivery (18%) and preeclampsia (8%). Except for one …
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RK Chaudhary, C Nepal, N Khanal, R Pathak, S Giri… - Cardiovascular & Hematological Agents in Medicinal …, 2015