作者
Juan Carlos Climent Pardo, Anna Zapaishchykova, Aidan Boyd, Divyanshu Tak, Maryamalsadat Mahootiha, Zezhong Ye, Ali Nabavizadeh, Sridhar Vajapeyam, Ariana Familiar, Pratiti Bandopadhayay, Hugo Aerts, Daphne A Haas-Kogan, Tina Young Poussaint, Benjamin Harris Kann
发表日期
2024/6/1
来源
Journal of Clinical Oncology
卷号
42
期号
16_suppl
页码范围
2066-2066
出版商
American Society of Clinical Oncology
简介
2066
Background: Pediatric low-grade gliomas (pLGGs) have heterogeneous clinical presentations and prognoses. Given the morbidity of treatment, some suspected pLGGs, especially those found incidentally, are surveilled without treatment, though the natural histories of these tumors have yet to be systematically studied. We leveraged deep learning and multi-institutional data to methodically analyze longitudinal volumetric trajectories of pLGGs on surveillance, yielding insights into their growth trajectories and clinical implications. Methods: We conducted a pooled, retrospective study of pLGG patients diagnosed between 1992 and 2020 from two sources (Dana-Farber Cancer Institute/Boston Children’s Hospital and the Children's Brain Tumor Network), who were surveilled untreated for at least one-year post-diagnosis and who had linked clinical data and longitudinal MRI available. We applied a validated …
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