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This paper deals with hybrid flow-shop scheduling problem with rework. In this problem, jobs are inspected at the last stage, and poorly processed jobs were returned and processed again. Thus, a job may visit a stage more than once, and we have a hybrid flow-shop with re-entrant flow. This kind of a shop may occur in many industries, such as final inspection system in automotive manufacturing. The criterion is to minimize the makespan of the system. We developed a 0–1 mixed-integer program of the problem. Since the hybrid flow-shop scheduling problem is NP-hard, an algorithm for finding an optimal solution in polynomial time does not exist. So we generalized some heuristic methods based on several basic dispatching rules and proposed a variable neighbourhood search (VNS) for the problem with sequence-dependent set-up times and unrelated parallel machines. The computational experiments show …