作者
Gerald S Wilkinson, Danielle M Adams, Amin Haghani, Ake T Lu, Joseph Zoller, Charles E Breeze, Bryan D Arnold, Hope C Ball, Gerald G Carter, Lisa Noelle Cooper, Dina KN Dechmann, Paolo Devanna, Nicolas J Fasel, Alexander V Galazyuk, Linus Günther, Edward Hurme, Gareth Jones, Mirjam Knörnschild, Ella Z Lattenkamp, Caesar Z Li, Frieder Mayer, Josephine A Reinhardt, Rodrigo A Medellin, Martina Nagy, Brian Pope, Megan L Power, Roger D Ransome, Emma C Teeling, Sonja C Vernes, Daniel Zamora-Mejías, Joshua Zhang, Paul A Faure, Lucas J Greville, L Gerardo Herrera M, José J Flores-Martínez, Steve Horvath
发表日期
2021/3/12
期刊
Nature communications
卷号
12
期号
1
页码范围
1615
出版商
Nature Publishing Group UK
简介
Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes …
学术搜索中的文章
GS Wilkinson, DM Adams, A Haghani, AT Lu, J Zoller… - Nature communications, 2021