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This study proposes a novel heterogeneous ensemble machine learning methodology to predict the concentration of asiaticoside in Centella asiatica (CA-CA) in the context of the lack of an effective prediction method capable of accurately estimating its quantity based on various growing environmental factors. The accurate prediction of the asi-aticoside concentration in CA-CA holds great significance in optimizing cultivation practices and improving the efficacy of the derived medicinal products. The presented approach aims to address this crucial need by employing a diverse ensemble of machine learning techniques. The proposed model integrates several machine learning tech-niques, including the standard long short-term memory (LSTM), gated recurrent unit (GRU), convolutional long short-term memory (ConvLSTM), and attention-based LSTM, by utilizing a differential evolution algorithm to optimize the …