作者
Manjinder S Sandhu, Dawn M Waterworth, Sally L Debenham, Eleanor Wheeler, Konstantinos Papadakis, Jing Hua Zhao, Kijoung Song, Xin Yuan, Toby Johnson, Sofie Ashford, Michael Inouye, Robert Luben, Matthew Sims, David Hadley, Wendy McArdle, Philip Barter, Y Antero Kesäniemi, Robert W Mahley, Ruth McPherson, Scott M Grundy, Sheila A Bingham, Kay-Tee Khaw, Ruth JF Loos, Gérard Waeber, Inês Barroso, David P Strachan, Panagiotis Deloukas, Peter Vollenweider, Nicholas J Wareham, Vincent Mooser
发表日期
2008/2/15
期刊
The Lancet
卷号
371
期号
9611
页码范围
483-491
出版商
Elsevier
简介
Background
LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.
Methods
We used genome-wide association data from up to 11 685 participants with measures of circulating LDL-cholesterol concentrations across five studies, including data for 293 461 autosomal single nucleotide polymorphisms (SNPs) with a minor allele frequency of 5% or more that passed our quality control criteria. We also used data from a second genome-wide array in up to 4337 participants from three of these five studies, with data for 290 140 SNPs. We did replication studies in two independent populations consisting of up to 4979 participants. Statistical …
引用总数
学术搜索中的文章
MS Sandhu, DM Waterworth, SL Debenham… - The Lancet, 2008