作者
Michael N Weedon, Hana Lango, Cecilia M Lindgren, Chris Wallace, David M Evans, Massimo Mangino, Rachel M Freathy, John RB Perry, Suzanne Stevens, Alistair S Hall, Nilesh J Samani, Beverly Shields, Inga Prokopenko, Martin Farrall, Anna Dominiczak, Toby Johnson, Sven Bergmann, Jacques S Beckmann, Peter Vollenweider, Dawn M Waterworth, Vincent Mooser, Colin NA Palmer, Andrew D Morris, Willem H Ouwehand, Jing Hua Zhao, Shengxu Li, Ruth JF Loos, Inês Barroso, Panagiotis Deloukas, Manjinder S Sandhu, Eleanor Wheeler, Nicole Soranzo, Michael Inouye, Nicholas J Wareham, Mark Caulfield, Patricia B Munroe, Andrew T Hattersley, Mark I McCarthy, Timothy M Frayling
发表日期
2008/4/6
期刊
Nature genetics
卷号
40
期号
5
页码范围
575-583
出版商
Nature Publishing Group
简介
Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify genetic variants influencing adult human height, we used genome-wide association data from 13,665 individuals and genotyped 39 variants in an additional 16,482 samples. We identified 20 variants associated with adult height (P < 5 × 10−7, with 10 reaching P < 1 × 10−10). Combined, the 20 SNPs explain ∼3% of height variation, with a ∼5 cm difference between the 6.2% of people with 17 or fewer 'tall' alleles compared to the 5.5% with 27 or more 'tall' alleles. The loci we identified implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes. Finally, our results provide insights into the genetic …
引用总数
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MN Weedon, H Lango, CM Lindgren, C Wallace… - Nature genetics, 2008