作者
Seth S Martin, Michael J Blaha, Mohamed B Elshazly, Eliot A Brinton, Peter P Toth, John W McEvoy, Parag H Joshi, Krishnaji R Kulkarni, Patrick D Mize, Peter O Kwiterovich, Andrew P DeFilippis, Roger S Blumenthal, Steven R Jones
发表日期
2013/8/20
期刊
Journal of the American College of Cardiology
卷号
62
期号
8
页码范围
732-739
出版商
American College of Cardiology Foundation
简介
Objectives
The aim of this study was to compare Friedewald-estimated and directly measured low-density lipoprotein cholesterol (LDL-C) values.
Background
LDL-C is routinely estimated by the Friedewald equation to guide treatment; however, compatibility with direct measurement has received relatively little scrutiny, especially at levels <70 mg/dl now targeted in high-risk patients.
Methods
We examined 1,340,614 U.S. adults who underwent lipid profiling by vertical spin density gradient ultracentrifugation (Atherotech, Birmingham, Alabama) from 2009 to 2011. Following standard practice, Friedewald LDL-C was not estimated if triglyceride levels were ≥400 mg/dl (n = 30,174), yielding 1,310,440 total patients and 191,333 patients with Friedewald LDL-C <70 mg/dl.
Results
Patients were 59 ± 15 years of age and 52% were women. Lipid distributions closely matched those in the National Health and Nutrition …
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SS Martin, MJ Blaha, MB Elshazly, EA Brinton, PP Toth… - Journal of the American College of Cardiology, 2013