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While recognized as important, calculation of embodied energy and greenhouse gas (GHG) emissions associated with buildings, especially at a large scale, has scant literature. A model has been created for estimating the inventory of structural and non-structural materials and building components and their associated embodied energy and GHG emissions for the approximately 807,400 office buildings constructed in the United States between 1946 and 2018. The buildings were modeled using eight prototypical designs. We estimate that 1100–1300 million metric tons of materials are embodied in these 807,000 buildings (90% of which have just 1–3 floors), as well as 6–7 years' worth of national construction and demolition waste. In total, 6.5 billion Gigajoules of primary energy use (∼6% of the U.S.’s 2021 energy consumption) and 0.5 billion metric tons of carbon dioxide equivalent emissions (∼8% of the U.S.’s …