作者
Michael Diamond, Rita Chen, Xuping Xie, James Case, Xianwen Zhang, Laura VanBlargan, Yang Liu, Jianying Liu, John Errico, Emma Winkler, Naveenchandra Suryadevara, Stephen Tahan, Jackson Turner, Wooseob Kim, Aaron Schmitz, Mahima Thapa, David Wang, Andrianus Boon, Dora Pinto, Rachel Presti, Jane O’Halloran, Alfred Kim, Parakkal Deepak, Daved Fremont, Davide Corti, Herbert Virgin, James Crowe, Lindsay Droit, Ali Ellebedy, Pei-Yong Shi, Pavlo Gilchuk
发表日期
2021/2/10
期刊
Research square
出版商
American Journal Experts
简介
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic infecting more than 106 million people and causing 2.3 million deaths. The rapid deployment of antibody-based countermeasures has provided hope for curtailing disease and ending the pandemic 1. However, the emergence of rapidly-spreading SARS-CoV-2 variants in the United Kingdom (B. 1.1. 7), South Africa (B. 1.351), and elsewhere with mutations in the spike protein has raised concern for escape from neutralizing antibody responses and loss of vaccine efficacy based on preliminary data with pseudoviruses 2–4. Here, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera, and human sera from recipients of the Pfizer-BioNTech (BNT162b2) mRNA vaccine, we report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B. 1.1 …
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M Diamond, R Chen, X Xie, J Case, X Zhang… - Research square, 2021