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The present study was undertaken to evaluate the anti-depressant activity of Nymphaea Alba Flower (NAF) in albino mice. Forty eight adult albino mice (Swiss strain) weighing between 25-35 gr were chosen. 24 animals were assigned to forced swim test (FST) and 24 o tail suspension test (TST). In each model there were 4 groups. The control group received vehicle (10 ml/kg^-1, p.o.), the two test groups received ethanolic extract of Nymphaea Alba Flower 100, 200 mg kg^-1 and the standard, imipramine (10 mg/kg^-1, p.o.) p.o., respectively, 60 minutes prior to the acute study. In chronic study, the drugs were given orally once a day for 10 days and the last dose was given 60 minutes before the experiment. Duration of immobility was noted in FST and TST. Statistical analysis was performed using Mean±SEM and ANOVA followed by Dunnett's test. The p<0.05 was considered statistically significant. Ethanolic extract of …