作者
Marc Jan Bonder, René Luijk, Daria V Zhernakova, Matthijs Moed, Patrick Deelen, Martijn Vermaat, Maarten van Iterson, Freerk van Dijk, Michiel van Galen, Jan Bot, Roderick C Slieker, P Mila Jhamai, Michael Verbiest, H Eka D Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Wibowo Arindrarto, Szymon M Kielbasa, Iris Jonkers, Peter van't Hof, Irene Nooren, Marian Beekman, Joris Deelen, Diana van Heemst, Alexandra Zhernakova, Ettje F Tigchelaar, Morris A Swertz, Albert Hofman, André G Uitterlinden, René Pool, Jenny van Dongen, Jouke J Hottenga, Coen DA Stehouwer, Carla JH van der Kallen, Casper G Schalkwijk, Leonard H van den Berg, Erik W van Zwet, Hailiang Mei, Yang Li, Mathieu Lemire, Thomas J Hudson, P Eline Slagboom, Cisca Wijmenga, Jan H Veldink, Marleen MJ van Greevenbroek, Cornelia M van Duijn, Dorret I Boomsma, Aaron Isaacs, Rick Jansen, Joyce BJ van Meurs, Peter AC't Hoen, Lude Franke, Bastiaan T Heijmans, BIOS Consortium
发表日期
2016/12/5
期刊
Nature Genetics
出版商
Nature Research
简介
Most disease-associated genetic variants are noncoding, making it challenging to design experiments to understand their functional consequences,. Identification of expression quantitative trait loci (eQTLs) has been a powerful approach to infer the downstream effects of disease-associated variants, but most of these variants remain unexplained,. The analysis of DNA methylation, a key component of the epigenome,, offers highly complementary data on the regulatory potential of genomic regions,. Here we show that disease-associated variants have widespread effects on DNA methylation in trans that likely reflect differential occupancy of trans binding sites by cis-regulated transcription factors. Using multiple omics data sets from 3,841 Dutch individuals, we identified 1,907 established trait-associated SNPs that affect the methylation levels of 10,141 different CpG sites in trans (false discovery rate (FDR) < 0.05 …
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MJ Bonder, R Luijk, DV Zhernakova, M Moed… - Nature genetics, 2017