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Resting state-functional connectivity (RS-FC) studies have provided evidence of brain alterations in the absence of any stimulus or task in persons with knee osteoarthritis pain (OA). However, RS-FC has been poorly characterized with respect to different degrees of clinical and experimental pain in this population. The present study examined RS-FC associations with self-reported measures of clinical knee pain (i.e., pain subscale of the Western Ontario and McMaster Universities Osteoarthritis Index-WOMAC) as well as experimental pain (i.e., thermal and mechanical stimuli) in a middle-to-older age knee OA cohort (n=187). We employed CONN (ver.20b) to calculate RS-FC among a standard set of 32 region-of-interests (ROI). We used a General Linear Model approach controlling for sex, age, study site, and race. Two-tailed False Discovery Rate statistical significance across ROI-to-ROI connections was set to α<0 …