作者
Chavier Laffitte, Benjamin G Griffith, Jessie Somerville, Julio A Peraza, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, James H Cole, Roger B Fillingim, Yenisel Cruz-Almeida
发表日期
2021/5/1
期刊
The Journal of Pain
卷号
22
期号
5
页码范围
589
出版商
Churchill Livingstone
简介
We have previously reported that older adults with chronic musculoskeletal pain had significantly older-appearing brains compared to older controls in a small, mainly Non-Hispanic white sample of individuals. We employed a machine-learning derived brain aging biomarker that compares voxel-wise gray and white matter volume images to a statistical model that accurately predicts chronological age from neuroimaging data in healthy people. The present study aimed to extend our previous findings to a larger, younger, and more racially diverse sample of individuals with knee osteoarthritis (OA) pain. Participants (mean age=58 years) with severe (n=100) and mild knee pain (n=51) as well as age-matched controls (n=54) completed demographic, psychological and self-reported and experimental pain assessments along with a T1-weighted MRI scan. We estimated a brain-predicted age difference (brain-PAD …
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C Laffitte, BG Griffith, J Somerville, JA Peraza… - The Journal of Pain, 2021