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In this study, sorghum, foxtail millet and proso millet extracts were evaluated by various in vitro antioxidant assays, including 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging activity, reducing power by Fe3+-Fe2+ transformation, and anti-lipid peroxidative activity by ferric thiocyanate. The sorghum extract contained high amount of phenolic compounds as well as a high level of antioxidant activity compared with foxtail millet and proso millet extracts. In addition, among the sorghum cultivar, me-susu (Sorghum dochna var. technicum, Snowden) extracts exhibited high levels of free radical scavenging activity, anti-oxidant capacity and anti-lipid peroxidative activity compared with-tocopherol. Taken together, these findings suggest that me-susu extracts can be considered good sources of natural anti-oxidants.