作者
Frederik N Engsig, Robert Zangerle, Olga Katsarou, Francois Dabis, Peter Reiss, John Gill, Kholoud Porter, Caroline Sabin, Andrew Riordan, Gerd Fätkenheuer, Félix Gutiérrez, Francois Raffi, Ole Kirk, Murielle Mary-Krause, Christoph Stephan, Patricia Garcia De Olalla, Jodie Guest, Hasina Samji, Antonella Castagna, Antonella d'Arminio Monforte, Adriane Skaletz-Rorowski, Jose Ramos, Giuseppe Lapadula, Cristina Mussini, Lluís Force, Laurence Meyer, Fiona Lampe, Faroudy Boufassa, Heiner C Bucher, Stéphane De Wit, Greer A Burkholder, Ramon Teira, Amy C Justice, Tim R Sterling, Heidi M. Crane, Jan Gerstoft, Jesper Grarup, Margaret May, Geneviève Chêne, Suzanne M Ingle, Jonathan Sterne, Niels Obel, Antiretroviral Therapy Cohort Collaboration (ART-CC) and the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord, Frederik N Engsig, Robert Zangerle, Olga Katsarou, Francois Dabis, Peter Reiss, John Gill, Kholoud Porter, Caroline Sabin, Andrew Riordan, Gerd Fätkenheuer, Félix Gutiérrez, Francois Raffi, Ole Kirk, Murielle Mary-Krause, Christoph Stephan, Patricia Garcia de Olalla, Jodie Guest, Hasina Samji, Antonella Castagna, Antonella d'Arminio Monforte, Adriane Skaletz-Rorowski, Jose Ramos, Giuseppe Lapadula, Cristina Mussini, Lluís Force, Laurence Meyer, Fiona Lampe, Faroudy Boufassa, Heiner C Bucher, Stéphane De Wit, Greer Burkholder, Ramon Teira, Amy Justice, Tim R Sterling, Heidi M Crane, Jan Gerstoft, Jesper Grarup, Margaret May, Geneviève Chêne, Suzanne M Ingle, Jonathan Sterne, Andrew Boulle, Hans-Reinhard Brodt, Jordi Casabona, Matthias Cavassini, Geneviève Chêne, Dominique Costagliola, François Dabis, Antonella D'Arminio Monforte, Julia del Amo, Ard Van Sighem, Gerd Fätkenheuer, John Gill, Jodie Guest, David Hans-Ulrich Haerry, Robert Hogg, Amy Justice, Amanda Mocroft, Niels Obel, Mari Kitahata, Fiona Lampe, Peter Reiss, Michael Saag, Tim R Sterling, Ramon Teira, Matthew Williams, Robert Zangerle, Suzanne Ingle, Margaret May, Jonathan Sterne, Robert Zangerle, Giota Touloumi, Josiane Warszawski, Laurence Meyer, François Dabis, Murielle Mary Krause, Jade Ghosn, Catherine Leport, Peter Reiss, Ferdinand Wit, Maria Prins, Heiner C Bucher, Caroline Sabin, Diana Gibb, Gerd Fätkenheuer, Julia Del Amo, Niels Obel, Claire Thorne, Amanda Mocroft, Ole Kirk, Christoph Stephan, Santiago Pérez-Hoyos, Osamah Hamouda, Barbara Gussenheimer-Bartmeyer, Antoni Noguera-Julian, Andrea Antinori, Antonella d'Arminio Monforte, Norbert Brockmeyer, José Ramos, Manuel Battegay, Andri Rauch, Cristina Mussini, Pat Tookey, Jordi Casabona, Jose M Miró, Antonella Castagna, Stephane de Wit
发表日期
2014/5/1
期刊
Clinical infectious diseases
卷号
58
期号
9
页码范围
1312-1321
出版商
Oxford University Press
简介
Background. Some human immunodeficiency virus (HIV)–infected individuals initiating combination antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but not CD4 cell recovery. We aimed to identify (1) risk factors for failure to achieve CD4 count >200 cells/µL after 3 years of sustained viral suppression and (2) the association of the achieved CD4 count with subsequent mortality.
Methods. We included treated HIV-infected adults from 2 large international HIV cohorts, who had viral suppression (≤500 HIV type 1 RNA copies/mL) for >3 years with CD4 count ≤200 cells/µL at start of the suppressed period. Logistic regression was used to identify risk factors for incomplete CD4 recovery (≤200 cells/µL) and Cox regression to identify associations with mortality.
Results. Of 5550 eligible individuals, 835 (15%) did not …
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FN Engsig, R Zangerle, O Katsarou, F Dabis, P Reiss… - Clinical infectious diseases, 2014