2022/4/12上传
作者
Ibadete Bytyci, Gani Bajraktari, Deepak L Bhatt, Charity J Morgan, Ali Ahmed, Wilbert S Aronow, Maciej Banach, Lipid and Blood Pressure Meta-analysis Collaboration
发表日期
2017/5/1
来源
Journal of Clinical Lipidology
卷号
11
期号
3
页码范围
624-637
出版商
Elsevier
简介
Introduction
Some available experimental studies have reported that hydrophilic statins might have advantages compared with lipophilic statins in patients with coronary artery disease (CAD). Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) investigating the potential differences of lipophilic and hydrophilic statins in patients with CAD.
Methods
We systematically searched selected electronic databases up to September 2016 to select RCTs, which compared clinical outcomes of hydrophilic vs lipophilic statins. Primary endpoints were cardiovascular (CV) events: major adverse cardiac events, myocardial infarction, cardiac revascularization, stroke, CV death, CV hospitalization, and all-cause mortality. Secondary endpoints were safety parameters: drug discontinuation, statin-associated muscle symptoms and alanine aminotransferase level increase.
Results
A total of 11,697 patients from …
学术搜索中的文章
I Bytyci, G Bajraktari, DL Bhatt, CJ Morgan, A Ahmed… - Journal of Clinical Lipidology, 2017