作者
Monire Hajimoradi, Zuhair Mohammad Hassan, Ali Akbar Pourfathollah, Saeed Daneshmandi, Nafiseh Pakravan
发表日期
2009/12/10
期刊
Journal of ethnopharmacology
卷号
126
期号
3
页码范围
565-570
出版商
Elsevier
简介
ETHNOPHARMACOLOGICAL RELEVANCE
Shark Liver Oil (SLO) is a traditional medicine that has been widely used in Scandinavian folk to augment the immune response in some immune-related diseases, especially as an anti-cancer agent.
AIM OF THE STUDY
The object of this project was to confirm the anti-cancer effect of SLO and the possible involving mechanisms.
MATERIALS AND METHODS
Using delayed-type hypersensitivity (DTH) response in normal mice, the optimal dose for stimulation of cellular immunity was obtained and injected intraperitoneally to the tumor-bearing mice. Cytokine pattern of splenic MNCs was tested by ELISA. The percentage of CD4+ and CD8+ lymphocytes in tumor-infiltrating lymphocytes was determined by flow cytometry. Also the rate of increase in tumor volume measured.
RESULTS
Our findings indicated that SLO highly augments delayed-type hypersensitivity response …
学术搜索中的文章
M Hajimoradi, ZM Hassan, AA Pourfathollah… - Journal of ethnopharmacology, 2009