作者
Alexander Domling, Wei Wang, Kan Wang
发表日期
2012/6/13
来源
Chemical reviews
卷号
112
期号
6
页码范围
3083-3135
出版商
American Chemical Society
简介
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are incorporated in the final product.(1) Several descriptive tags are regularly attached to MCRs (Figure 1): they are atom economic, for example, the majority if not all of the atoms of the starting materials are incorporated in the product; they are efficient, for example, they efficiently yield the product since the product is formed in one-step instead of multiple sequential steps; they are convergent, for example, several starting materials combine in one reaction to form the product; they exhibit a very high bond-forming-index (BFI), for example, several non-hydrogen atom bonds are formed in one synthetic transformation.(2) Therefore MCRs are often a useful alternative to sequential multistep synthesis.
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