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Firms currently operate in highly competitive scenarios, where the environmental conditions evolve over time. Many factors intervene simultaneously and their hard-to-interpret interactions throughout the supply chain greatly complicate decision-making. The complexity clearly manifests itself in the field of inventory management, in which determining the optimal replenishment rule often becomes an intractable problem. This paper applies machine learning to help managers understand these complex scenarios and better manage the inventory flow. Building on a dynamic framework, we employ an inductive learning algorithm for setting the most appropriate replenishment policy over time by reacting to the environmental changes. This approach proves to be effective in a three-echelon supply chain where the scenario is defined by seven variables (cost structure, demand variability, three lead times, and two partners …