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The dissemination of patients' medical records results in diverse risks to patients' privacy as malicious activities on these records cause severe damage to the reputation, finances, and so on of all parties related directly or indirectly to the data. Current methods to effectively manage and protect medical records have been proved to be insufficient. In this paper, we propose MeDShare, a system that addresses the issue of medical data sharing among medical big data custodians in a trust-less environment. The system is blockchain-based and provides data provenance, auditing, and control for shared medical data in cloud repositories among big data entities. MeDShare monitors entities that access data for malicious use from a data custodian system. In MeDShare, data transitions and sharing from one entity to the other, along with all actions performed on the MeDShare system, are recorded in a tamper-proof …