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It is generally recognized that obesity and cardiometabolic risk are more prevalent in African Americans. Kallistatin, a novel tissue kallikrein inhibitor, has anti-inflammatory and anti-oxidant properties. Thus, the goal of this study was to examine the relationships among plasma kallistatin levels, adiposity and cardiometabolic risk factors in African American adolescents.

Plasma kallistatin levels were determined in 318 apparently healthy African American adolescents (aged 14–19years, 48.1% females) by enzyme-linked immunosorbent assay.

Plasma kallistatin levels did not differ between males (27.9±11.2μg/mL) and females (26.8±11.0μg/mL) (p=0.47). Plasma kallistatin levels were inversely correlated with percent body fat (% BF, r=−0.13, p=0.04), total cholesterol (r=−0.28, p<0.01), low density lipoprotein cholesterol (LDL, r=−0.30, p<0.01) and interleukin-6 (r=−0.14 …