作者
Daniel Gordin, Hetal Shah, Takanori Shinjo, Ronald St-Louis, Weier Qi, Kyoungmin Park, Samantha M Paniagua, David M Pober, I-Hsien Wu, Vanessa Bahnam, Megan J Brissett, Liane J Tinsley, Jonathan M Dreyfuss, Hui Pan, Yutong Dong, Monika A Niewczas, Peter Amenta, Thorsten Sadowski, Aimo Kannt, Hillary A Keenan, George L King
发表日期
2019/7/1
期刊
Diabetes care
卷号
42
期号
7
页码范围
1263-1273
出版商
American Diabetes Association
简介
OBJECTIVE
Elevated glycolytic enzymes in renal glomeruli correlated with preservation of renal function in the Medalist Study, individuals with ≥50 years of type 1 diabetes. Specifically, pyruvate kinase M2 (PKM2) activation protected insulin-deficient diabetic mice from hyperglycemia-induced glomerular pathology. This study aims to extend these findings in a separate cohort of individuals with type 1 and type 2 diabetes and discover new circulatory biomarkers for renal protection through proteomics and metabolomics of Medalists’ plasma. We hypothesize that increased glycolytic flux and improved mitochondrial biogenesis will halt the progression of diabetic nephropathy.
RESEARCH DESIGN AND METHODS
Immunoblots analyzed selected glycolytic and mitochondrial enzymes in postmortem glomeruli of non-Medalists with type 1 diabetes (n = 15), type 2 diabetes (n = 19), and …
学术搜索中的文章
D Gordin, H Shah, T Shinjo, R St-Louis, W Qi, K Park… - Diabetes care, 2019