作者
Kimberly J Reidy, Rebecca C Hjorten, Claire L Simpson, Avi Z Rosenberg, Stacy D Rosenblum, Csaba P Kovesdy, Frances A Tylavsky, Joseph Myrie, Bianca L Ruiz, Soulin Haque, Khyobeni Mozhui, George W Nelson, Victor A David, Xiaoping Yang, Masako Suzuki, Jack Jacob, Sandra E Reznik, Frederick J Kaskel, Jeffrey B Kopp, Cheryl A Winkler, Robert L Davis
发表日期
2018/9/6
期刊
The American Journal of Human Genetics
卷号
103
期号
3
页码范围
367-376
出版商
Cell Press
简介
Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is expressed in human placenta and transgenic mice expressing APOL1 develop preeclampsia. We evaluated the role of APOL1 variants in human preeclampsia. We determined maternal and fetal APOL1 genotypes in black women with preeclampsia in two populations. At Einstein Montefiore Center (EMC) Affiliated Hospitals, we studied 121 pregnancies in black women with preeclampsia. At University of Tennessee Health Science Center (UTHSC), we studied 93 pregnancies in black women with preeclampsia and 793 pregnancies without preeclampsia. We measured serum markers of preeclampsia soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng). Fetal APOL1 high-risk (HR …
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KJ Reidy, RC Hjorten, CL Simpson, AZ Rosenberg… - The American Journal of Human Genetics, 2018