作者
Pirro G Hysi, Ching-Yu Cheng, Henriët Springelkamp, Stuart Macgregor, Jessica N Cooke Bailey, Robert Wojciechowski, Veronique Vitart, Abhishek Nag, Alex W Hewitt, René Höhn, Cristina Venturini, Alireza Mirshahi, Wishal D Ramdas, Gudmar Thorleifsson, Eranga Vithana, Chiea-Chuen Khor, Arni B Stefansson, Jiemin Liao, Jonathan L Haines, Najaf Amin, Ya Xing Wang, Philipp S Wild, Ayse B Ozel, Jun Z Li, Brian W Fleck, Tanja Zeller, Sandra E Staffieri, Yik-Ying Teo, Gabriel Cuellar-Partida, Xiaoyan Luo, R Rand Allingham, Julia E Richards, Andrea Senft, Lennart C Karssen, Yingfeng Zheng, Céline Bellenguez, Liang Xu, Adriana I Iglesias, James F Wilson, Jae H Kang, Elisabeth M Van Leeuwen, Vesteinn Jonsson, Unnur Thorsteinsdottir, Dominiek DG Despriet, Sarah Ennis, Sayoko E Moroi, Nicholas G Martin, Nomdo M Jansonius, Seyhan Yazar, E-Shyong Tai, Philippe Amouyel, James Kirwan, Leonieke ME Van Koolwijk, Michael A Hauser, Fridbert Jonasson, Paul Leo, Stephanie J Loomis, Rhys Fogarty, Fernando Rivadeneira, Lisa Kearns, Karl J Lackner, Paulus TVM De Jong, Claire L Simpson, Craig E Pennell, Ben A Oostra, André G Uitterlinden, Seang-Mei Saw, Andrew J Lotery, Joan E Bailey-Wilson, Albert Hofman, Johannes R Vingerling, Cécilia Maubaret, Norbert Pfeiffer, Roger CW Wolfs, Hans G Lemij, Terri L Young, Louis R Pasquale, Cécile Delcourt, Timothy D Spector, Caroline CW Klaver, Kerrin S Small, Kathryn P Burdon, Kari Stefansson, Tien-Yin Wong, BMES GWAS Group, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2, Ananth Viswanathan, David A Mackey, Jamie E Craig, Janey L Wiggs, Cornelia M van Duijn, Christopher J Hammond, Tin Aung
发表日期
2014/10
期刊
Nature genetics
卷号
46
期号
10
页码范围
1126-1130
出版商
Nature Publishing Group US
简介
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10−8 for rs6445055), two on chromosome 9 (P = 2.80 × 10−11 for rs2472493 near ABCA1 and P = 6.39 × 10−11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10−11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of …
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PG Hysi, CY Cheng, H Springelkamp, S Macgregor… - Nature genetics, 2014